Among the confounding challenges of diagnosing and treating Alzheimer's disease (AD) is the fact that patients with asymptomatic and symptomatic versions of the degenerative condition may share similar neuropathological burdens but experience significantly different rates of cognitive decline.
source https://www.lifetechnology.com/blogs/life-technology-news-blog/researchers-map-protein-gene-interactions-involved-in-alzheimers-disease